See the Mechanism, Not Just the Fact
Ask a question the way you would in a chat — about a drug, a mutation, a resistance mechanism, or a vaccine — and Surface 2 pulls up the relevant 3D structure automatically, picks the right model for the job, and highlights what matters.
Four tools, picked automatically based on your question
Fastest option. Use for quick structure lookups, screening many variants at once, or any time you just need a first look.
Best for seeing how a drug binds to its target — docking, resistance mechanisms, multi-part protein assemblies.
Best for antibody/antigen and vaccine-related questions — shows how immune molecules recognize their targets.
Handles the most complex cases — proteins bound to DNA, RNA, or small molecules together.
Pick a topic — opens in your Workspace with everything pre-loaded
The 3D structure of the target protein loads automatically, with the binding pocket highlighted and key active-site residues labeled. A short explanation walks through why the drug fits — or doesn't fit — that pocket.
Side-by-side structures of the normal and mutated protein, so you can directly see what changed — a shape difference, a new exposed surface, a destabilized region — and how that change leads to the disease.
A split view comparing the normal drug target to the resistant version, showing exactly how the binding site changed so the drug no longer fits. Linked notes explain what alternative treatments work and why.
The antibody-antigen interaction rendered in 3D with the key recognition sites (epitopes) highlighted, plus an explanation of how the shape of the interaction affects how well a vaccine works.
A view of the flexible, shifting shapes these proteins can take, showing how a normal protein can fold into a harmful clumped form — and where current drugs try to intervene in that process.
The channel structure with its pore and voltage-sensing regions labeled, and the exact mutation location highlighted so you can see how a small change disrupts how the channel works.